Faculty Scholarship: Dr. Walter Patton

Dr. Patton



Walter A. Patton

Associate Professor of Chemistry

B.S. Susquehanna University
Ph.D.
Lehigh University
Postdoctoral Fellow
National Institutes of Health

 

Dr. Patton is interested in the structure-function relationships in proteins. Most recently his work focuses on the features of E. coli GMP synthetase that facilitates ammonia transfer from a domain where it is synthesized to the domain in which it is utilized. His work integrates chemical, biochemical and molecular biological methods (e.g. polymerase chain reaction) to make "designer" proteins at the DNA level. Once expressed in bacteria, these proteins are purified in order to study their function.

Dr. Patton's Scholarship and Pedagogy 2016 Celebration

Dissinger, K. N., & Patton, W. A. Limited-proteolysis of the E. coli GMP synthetase ATPP domain reveals a compact dimer

core. Poster Presented at the 18th Annual Undergraduate Research Symposium in the Chemical and Biological

Sciences, University of Maryland, Baltimore, Md.

Dissinger, K. N., Van Nederveen, V. A., Meyer, M. O., Abbott, J. S., & Patton, W. A. E. coli  GMPS dimerization domain: 

Structural requirements and protease stability. Poster Presented at the Disappearing Boundaries Summer Research

Meeting, Lebanon Valley College, Annville, Pa.

Meyer, M. O., & Patton, W. A. Cross-linking studies to investigate stable dimer formation in E. coli GMPS. Poster Presented

at the 18th Annual Undergraduate Research Symposium in the Chemical and Biological Sciences, University of

Maryland, Baltimore, Md.

Misiewicz, L., Weidman, J., & Patton, W. A. [Ru(bpy)3]2+ as a luminescent sensor. Poster Presented at Inquiry 2015,

Lebanon Valley College, Annville, Pa.

Patton, W. A. (2015, March 24). Investigating enzyme assays. Paper Presented at the 249th National Meeting of the

American Chemical Society, Denver, Colo.

Pugh, R. J., Slee, J. B., Farwell, S. L. N., Li, Y., Barthol, T., Patton, W. A., & Lowe-Krentz, L. J. (2016, January 14).

Transmembrane protein 184A is a receptor required for vascular smooth muscle cell responses to heparin.  Journal of

Biological Chemistry. Advance online publication. doi:10.1074/jbc.M115.681122

Snyder, J. W., Marshall, C. M., Nye, D. A., Basehore, L., & Patton, W. A. (2015, July 17). GMPS stability and fibril/crystal

formation. Poster Presented at the Disappearing Boundaries Summer Research Meeting, Lebanon Valley College,

Annville, Pa.

Snyder, J. W., & Patton, W. A. Crystallization of E. coli GMP synthetase and insight from the structures formed. Poster

Presented at the 18th Annual Undergraduate Research Symposium in the Chemical and Biological Sciences,

University of Maryland, Baltimore, Md.

Dr. Patton's Scholarship and Pedagogy 2014 Celebration

McCardle, K., & Patton, W. (October 26, 2013). Limited proteolysis of E.coli GMP synthetase. 16th Annual Undergraduate Research Symposium in the Chemical and Biological Sciences, University of Maryland, Baltimore, MD.

Shultz, A., & Patton, W. (October 26, 2013). The effects of zinc sulfide nanoparticles on protein stability. 16th Annual Undergraduate Research Symposium in the Chemical and Biological Sciences, University of Maryland, Baltimore, MD.

Weilnau, J. N., Black, S. E., Chehata, V. J., Schmidt, M. P., Holt, K. L., Carl, L. M., . . . Patton, W.A. (2013). ZnS nanocrystal cytotoxicity is influenced by capping agent chemical structure and duration of time in suspension. Journal of Applied Toxicology, 33, 227-237.

Dr. Patton's Scholarship and Pedagogy 2013 Celebration

Hornberger A., Terry B. and Patton W.A. (2012) An assay for releasable fats from biosources: a simple and effective method for biofuel source material evaluation. Presented at the Philadelphia Section of the American Chemical Society, Annual Student Poster Session. Temple University, Phildephia, PA. February 23, 2012. Awarded first place in HS student division.

Bicher, T. S, Patton, W.A. Production and characterization of the dimerization domain of E. coli GMP synthetase. Presented at the 15th Annual Undergraduate Research Symposium in the Chemical and Biological Sciences, University of Maryland, Baltimore, MD, Oct 20, 2012. Presentation was judged as a first place winner in biochemistry division.

Weilnau, J.N., Black, S.E., Chehata, V.J., Schmidt, M.P., Holt, K.L., Carl, L.M., Straka, C.J., Marsh, A.L., Patton, W.A., Lappas, C.M. "ZnS Nanocrystal Cytotoxicity is Influenced by Capping Agent Chemical Structure and Duration of Time in Suspension," Journal of Applied Toxicology, 2012, doi: 10.1012/jat.2811.

Dr. Patton's Scholarship and Pedagogy 2012 Celebration

Funk, K. R., Irvin, L. N., Patton, W. A., & Irvin, L. N. (2011). Investigations into the stability of the ATPP domain of E coli GMPS. 14th Annual Undergraduate Research Symposium in the Chemical and Biological Sciences, Baltimore, MD.

Funk, K. R., & Patton, W. A. (2011). Investigations into the stability of the ATPP domain of E coli GMPS. Eastern Regional Meeting of the Biophysical Society, Hershey, PA.

Holt, K. L., & Patton, W. A. (2011). Synthesis and characterization of peptide-capped ZnS nanoparticles. 46th Midwest, 39th Great Lakes, Joint Regional ACS Meeting, Saint Louis, MO.

Holt, K. L., & Patton, W. A. (2011). Synthesis and chracterization of peptide-capped ZnS nanoparticles. 14th Annual Undergraduate Research Symposium in the Chemical and Biological Sciences, Baltimore, MD. Awarded second place in biochemistry division.

Patton, W. A., Delaney, C. L., & Carr, R. (2011). Pancreatic lipase: Enzyme biochemistry from the health food store. ASBMB Annual Meeting, Washington, D.C.

Washburn, H. R., Delaney, C. L., & Patton, W. A. (2011). Approaches to the MALDI-TOF mass spectral analysis of a membrane-bound protein. 14th Annual Undergraduate Research Symposium in the Chemical and Biological Sciences, Baltimore, MD.